新冠肺炎病毒結合ACE2受體之後,要藉由
TMPRSS2在棘蛋白上切一下,病毒才會翻轉過來進入細胞膜裡面,目前TMPRSS2有一個強力丶安全丶有效又便宜的抑制性藥物,一次一顆丶一天三次就可以顯著減少住院丶插管跟死亡率,並減少照顧新冠肺炎病人的醫療人員被傳染新冠肺炎,它學名bromhexine hydrochloride,就是常用的bisolven ,可用來預防新冠肺炎病毒進入細胞,這個藥慢性肺病的病人都吃一輩子,一般認為幾乎像味素藥一樣,除非個人體質過敏,否則幾乎沒有副作用。在針對新冠肺炎方面,主要用於預防,如果用疫苗有效率的計算方法來算的話,由對照組的七個被感染降到兩個被感染,有效率71%,跟一般疫苗效果差不多,而且它所抑制的這一個TMPRSS2,被抑制後人體也沒有什麼影響。而且安全劑量極高,用於治療的話,一次可以用四顆,一天用到12顆,也沒有明顯的副作用。價格又很便宜,以下附兩篇報告。
1. https://www.medrxiv.org/content/10.1101/2021.03.03.21252855v1
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502909/
及一篇綜合回顧文獻
3. https://www.clinmedjournals.org/articles/jide/journal-of-infectious-diseases-and-epidemiology-jide-6-135.php?jid=jide

Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study

Background Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of the SARS-CoV-2 into cells. We aimed t o assess the preventive potential of regula

https://www.medrxiv.org/content/10.1101/2021.03.03.21252855v1
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Lin mark this message contains misinformation
originally written by Lin
假的,化痰藥是針對症狀使用,就醫時由醫師就患者病情綜合判斷後處方使用,有症狀的新冠肺炎,病患常有濃稠的呼吸道分泌物,因此由醫師處方化痰藥會有幫助。但化痰藥並沒有預防新冠肺炎效果。

References

https://806.mnd.gov.tw/ph/Med_Web/efiles/EBIS2.pdf

https://www.commonhealth.com.tw/article/86371

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