每日一則:科學家們將自然殺手細胞的過度活躍反應,與發生在幼兒身上的膽道閉鎖症(一種會導致嚴重的肝臟受損以及死亡的膽道阻塞疾病)之間關連在一起。失控的免疫系統會導致肝臟受損、肝硬化及肝癌的疾病。細胞激素是一種會在肝臟引發炎症的免疫物質,而許多肝病是由細胞激素的產生所導致的。《國際季刊17》
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Pei-Chi Lo mark this message contains true information
originally written by Pei-Chi Lo
① 嬰兒膽道閉鎖是指連接肝臟、十二指腸的膽道不通,導致膽汁無法運送至腸道,持續累積在肝臟,的確可能導致肝硬化,肝衰竭甚至致命。

② 包括《臨床病理學期刊》、《兒科研究》等期刊的確皆有相關論文,探討NK Cells(自然殺手細胞)可能與膽道閉鎖的導管上皮、膽管傷害有關。

References

2012年《兒科研究》-Combinatory effects of hepatic CD8+ and NK lymphocytes in bile duct injury from biliary atresia:
https://pubmed.ncbi.nlm.nih.gov/22476047/

2013年《臨床病理學期刊》-Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia:
https://pubmed.ncbi.nlm.nih.gov/23162109/

台大醫院電子報-嬰兒膽道閉鎖:
https://epaper.ntuh.gov.tw/health/201804/health_2.html

國民健康署-認識膽道閉鎖:
https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=1593&pid=6478

Combinatory effects of hepatic CD8+ and NK lymphocytes in bile duct injury from biliary atresia - PubMed

Specific immune responses from NK and CD8(+) cells were involved in the injury to the duct epithelium and play a significant role in the phenotype of experimental biliary atresia.

https://pubmed.ncbi.nlm.nih.gov/22476047/

Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia - PubMed

CD56(-)CD16(+) NK cells with reduced NK activity may be involved in the bile duct damage in BA, and CD16(+) NK cells expressing CX3CR1 may be attracted by and interact with bile ducts expressing CX3CL

https://pubmed.ncbi.nlm.nih.gov/23162109/

嬰兒膽道閉鎖  作者:臺大醫院護理部錢佳慧護理長   保健園地  2018年4月臺大醫院健康電子報

「嬰兒膽道閉鎖」指連接肝臟與十二指腸間的膽道完全不通了。當膽道不通時,肝外管腔都封閉,造成膽汁無法運送到腸道,累積在肝臟就會產生肝硬化的可能,若未及早診斷治療甚至會造成肝臟變大且變硬,長久未治療甚至會因肝硬化、肝衰竭而致命,所以嬰兒膽道閉鎖需要及早診斷與手術治療…。關鍵字:嬰兒膽道閉鎖,膽道閉鎖,膽囊,膽汁,黃疸,嬰兒大便卡,經皮肝穿刺檢查,腹部超音波,核磁共振,葛西手術,Kasai,膽道炎,中鏈

https://epaper.ntuh.gov.tw/health/201804/health_2.html

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