阿茲海默症(Alzheimer’s disease)疾病對於病人及家屬皆會帶來很大的影響,然而至目前為止,疾病的發生機轉及可能的治療方式卻仍在研究階段。《Cell Reports》日前刊登中國山西醫科大學(Shanxi Medical University)的最新發表,研究團隊表示,原先發展用來治療糖尿病的特定藥物,有機會反轉阿茲海默症的記憶喪失症狀。第二型糖尿病已知為阿茲海默症的風險因子之一,其病程會影響到胰島素的分泌,而在過去的研究中亦曾發現,這個影響人體血糖調節的荷爾蒙,其分泌不足可能與大腦的退化情形有關。本篇研究中,作者發現結合第二型糖尿病的特定藥物,可能改善數項阿茲海默症的獨特病徵。作者表示,這項研究發現,有助於未來發展阿茲海默症及其它神經退化疾病的新治療方法。

新聞出處:Alzheimer's treatment: Diabetes drug holds promise for fighting disease after 'significantly reversing' memory loss《Independent》
http://www.independent.co.uk/news/health/alzheimers-diabetes-drug-memory-loss-reverse-disease-treatment-degenerative-a8133681.html
研究刊登在《Cell Reports》第1678卷 第64-74頁
https://www.sciencedirect.com/science/article/pii/S0006899317304596

Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

AbstractType 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Previous studies have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insuli

https://www.sciencedirect.com/science/article/pii/S0006899317304596
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美國布朗大學沃倫阿爾伯特醫學院(The Warren Alpert Medical School of Brown University)的蘇珊教授(Suzanne de la Monte),後續發現阿茲海默症患者不一定有第一型或第二型糖尿病,但腦部也會出現血糖代謝異常的狀況,因此認為阿茲海默症和糖尿病有高度相似性,因此學者提出阿茲海默症為第三型糖尿病的說法。

References

http://www.cofit.me/229093913535506/4688052
飲食與生活習慣的改善,才是預防阿茲海默症的根本

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