Accelerated biological aging in COVID-19 patients
Nature Communications - Age is a risk factor for SARS-CoV-2 infection and severe disease. Here the authors perform DNA methylation analyses in whole blood from COVID-19 patients using established...
只要一確診後，無論是「輕症」或「重症」者，器官會「加速」老化3~4年，這是很可怕的事。你一定要看這影片!
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｜originally written by Pei-Chi Lo
■的確有多篇研究探討COVID-19加速生物老化的研究，例如：
Xue Cao等人於2022年4月發表於Nature Communications的研究，分析了232名健康人士和413名COVID-19患者血液檢體中的DNA甲基化，並發現在健康和發展為COVID-19的連續血液樣本中，表觀遺傳衰老、端粒損耗的速度越來越快。
然而研究也提及目前COVID-19與加速表觀遺傳衰老的因果關係仍未得到解答，且在不同研究中不同的表觀遺傳時鐘和資料集也有不同的結果。
■原訊息中「確診後器官會加速老化3-4年」的說法尚無足夠科學證據支持。
Xue Cao等人於2022年4月發表於Nature Communications的研究，分析了232名健康人士和413名COVID-19患者血液檢體中的DNA甲基化，並發現在健康和發展為COVID-19的連續血液樣本中，表觀遺傳衰老、端粒損耗的速度越來越快。
然而研究也提及目前COVID-19與加速表觀遺傳衰老的因果關係仍未得到解答，且在不同研究中不同的表觀遺傳時鐘和資料集也有不同的結果。
■原訊息中「確診後器官會加速老化3-4年」的說法尚無足夠科學證據支持。
Opinion Sources
Nature Communications-Accelerated biological aging in COVID-19 patientshttps://www.nature.com/articles/s41467-022-29801-8
Front Genet-Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination
https://pubmed.ncbi.nlm.nih.gov/35719387/
https://www.nature.com/articles/s41467-022-29801-8
Longitudinal Study of DNA Methylation and Epigenetic Clocks Prior to and Following Test-Confirmed COVID-19 and mRNA Vaccination - PubMed
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome. Specifically, aberrant DNA methy
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