紅黴素不只是抗生素 📌還可以抗多種病毒
(*)最近牙齦發炎腫痛和出血,每天用優碘漱口水多次,用兩天都沒改善,研判不是細菌牙齦炎而是細胞內病毒感染。於是早晚服用紅黴素和耐適恩,便好了。
(*)Macrolide抗生素,包括紅黴素、日舒和克拉黴素等,是抑菌性的抗生素。抗細菌之外,也有抗病毒、抗發炎和免疫調節的作用。
(*)紅黴素類能夠透過多重機轉來抑制多種病毒感染,包括黃病毒類 (登革熱、茲卡和黃熱病)、腸病毒、鼻病毒、呼吸道融合病毒、A型流感病毒、伊波拉病毒、普通感冒冠狀病毒以及新冠病毒等。
(*)A型流感病毒:日舒在H1N1感染早期能阻止從宿主細胞新出芽的子代病毒內化到細胞的過程,顯著抑制病毒的複製。單次鼻腔給予日舒成功治療H1N1感染小鼠,降低肺部病毒量並緩解症狀。
(*)感冒冠狀病毒:紅黴素在不同細胞都能直接抑制感冒冠狀病毒的感染,並在安全濃度下顯著降低病毒量,且無細胞毒性。它是透過破壞病毒外膜的完整性而滅活病毒,因此紅黴素能在感染初期抑制感冒冠狀病毒的感染。
(*)新冠病毒:日舒、克拉黴素和萊紅黴素都能直接抑制新冠病毒進入細胞,減少細胞內病毒 RNA 的累積和傳播,並防止病毒誘導的細胞死亡,但只在感染初期才有明顯抗病毒效果。
(*)有趣的是紅黴素、維生素B6和葉酸在安全濃度下,都能抑制新冠病毒在Vero 細胞中所誘導的細胞病變,並抑制新冠病毒的類木瓜蛋白酶和主要蛋白酶。
(*)紅黴素類的副作用有過敏、肝毒性、QT間期延長、心室心搏過速和胃腸道不適,因此有心臟傳導障礙和懷孕初期不建議使用。
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https://www.sciencedirect.com/science/article/pii/S0753332222000701
https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2163
https://www.nature.com/articles/s41429-019-0204-x
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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1273982/full

Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process

The Journal of Antibiotics - Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process

https://www.nature.com/articles/s41429-019-0204-x

Erythromycin Estolate Is a Potent Inhibitor Against HCoV-OC43 by Directly Inactivating the Virus Particle

In addition to antibacterial effects, macrolide antibiotics exhibit other extensive pharmacological effects, such as anti-inflammatory and antiviral activities. Erythromycin estolate, one of the macro

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301004/

Erythromycin, retapamulin, pyridoxine, folic acid, and ivermectin inhibit cytopathic effect, papain-like protease, and MPRO enzymes of SARS-CoV-2

BackgroundAlthough tremendous success has been achieved in the development and deployment of effective COVID-19 vaccines, developing effective therapeutics for the treatment of those who do come down

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1273982/full
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這則訊息提到紅黴素(一種抗生素)可以抗多種病毒,包括新冠病毒等。然而,這些資訊並非來自官方醫學機構或研究報告,而是引用了一些研究文章的內容。閱聽人需要特別留意的地方在於,這些資訊是否經過正式的醫學審查和確認,以及是否有其他研究支持這些主張。在面對健康相關資訊時,最好依然以官方醫學機構或專業醫療人員的建議為準。
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