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Pei-Chi Lo mark this message contains true information
originally written by Pei-Chi Lo
影片中的觀念皆有相關學術研究支持,所提預防方式亦與我國健康署立場相同:

■「Sister Mary」

在《Gerontologist》等期刊皆有其個案研究,Mary腦中的確有許多由β類澱粉蛋白質堆積形成的老年斑(senile plaques),但其認知測驗依然取得很高的分數。

■「1/3失智可預防」

源自《Lancet》2017年研究,其估測有【35%】失智症源自於九個危險因子:①低教育程度 ②中年高血壓 ③中年肥胖 ④聽力損失 ⑤老年抑鬱 ⑥糖尿病 ⑦缺乏運動 ⑧抽菸 ⑨社會疏離,並認為避免這些危險因子,失智將可被預防。

■「減少藍光可預防失智」

源自《NPJ Aging Mech Dis》2019年對果蠅的研究,每天將成年果蠅暴露於藍光12小時會加速衰老、腦神經病變。

■「睡覺有助預防失智」

源自《Science》2019年的研究,研究者發現睡眠中腦波呈慢波活動時,血液流量開始降低,接著有大量腦脊髓液湧入,這個「清洗大腦」的過程,有助於清掃與失智症高度相關的β類澱粉蛋白質。

■「減少頭痛可預防失智」

依《Headache》2020年的研究,偏頭痛是腦白質白斑(WMH)、缺血性中風的風險因子,此二者確實與失智症風險增加有關;但偏頭痛本身與失智症尚未被證實有直接性的關聯。

■「均衡飲食」、「少吃紅肉」、「避免吸菸」、「多社會活動」、「預防三高」等

皆與我國國健署對於失智預防方式的立場相同。

References

《Gerontologist》-Sister Mary個案研究的論文:
https://academic.oup.com/gerontologist/article/37/2/150/616995

《Lancet》-Prevention of dementia by targeting risk factors:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30578-6/fulltext

《Science》-Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep:
https://science.sciencemag.org/content/366/6465/628

《NPJ Aging Mech Dis》-Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797782/

《Headache》-Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192135/

國民健康署-失智症衛教及資源手冊:
https://health99.hpa.gov.tw/flipbook/21935/#p=5

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

During non–rapid eye movement sleep, low-frequency oscillations in neural activity support memory consolidation and neuronal computation. Sleep is also associated with increased interstitial fluid vol

https://science.sciencemag.org/content/366/6465/628

Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in Drosophila

Light is necessary for life, but prolonged exposure to artificial light is a matter of increasing health concern. Humans are exposed to increased amounts of light in the blue spectrum produced by ligh

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797782/

Migraine Headache and Risk of Dementia in the Atherosclerosis Risk in Communities Neurocognitive Study

We aimed to assess the association between migraine headache and incident dementia.Migraine is a risk factor for white matter hyperintensities and ischemic stroke, which are both associated with incre

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192135/

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